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Hair loss affects millions of individuals worldwide, causing significant distress and impacting self-esteem. Over the years, researchers have been striving to find effective solutions to combat this common condition. One potential breakthrough in the field of hair restoration is Baricitinib, an FDA-approved medication primarily used for the treatment of rheumatoid arthritis. Recent studies have highlighted its potential benefits for hair loss and hair transplant procedures, offering hope to those seeking effective remedies for their hair-related concerns.
Baricitinib is an oral medication belonging to the class of drugs known as Janus kinase (JAK) inhibitors. It works by inhibiting the activity of certain enzymes involved in the immune response. Originally developed to treat autoimmune disorders, its anti-inflammatory properties have shown promise in addressing hair loss, specifically androgenetic alopecia, also known as male or female pattern baldness.
Baricitinib To Treat Alopecia
On June 13, 2022, the FDA authorised Baricitinib as the first oral tablet to combat alopecia areata. Two clinical trials involving 1,200 participants with severe alopecia were conducted. After 36 weeks, nearly 40% of patients on the 4 mg dose experienced 80% hair growth, compared to 23% on the 2 mg dose and 5% on the placebo. Additionally, 45% of those on the 4 mg dose saw significant regrowth of eyelashes and eyebrows. This breakthrough offers hope to alopecia sufferers and represents a major advancement in treatment.
Benefits for Hair Loss
Targeting the Inflammatory Pathways
Androgenetic alopecia is associated with chronic inflammation around the hair follicles. By suppressing the inflammatory response, Baricitinib helps reduce follicular damage, potentially slowing down or halting hair loss progression. In a study published in the Journal of Investigative Dermatology, researchers found that Baricitinib promoted hair growth and increased hair density in mice models with alopecia areata.
Stimulating Hair Regrowth
Besides its anti-inflammatory effects, Baricitinib has been found to promote hair regrowth in clinical trials. Researchers have suggested that the drug’s mechanism of action involves reactivating dormant hair follicles, leading to the initiation of new hair growth. This regenerative potential offers a promising option for individuals seeking a non-invasive alternative to traditional hair transplant procedures.
Benefits for Hair Transplant
Enhanced Graft Survival
Hair transplant procedures involve harvesting hair follicles from the donor area and transplanting them into the recipient area. Baricitinib has shown promise in improving graft survival rates by reducing the inflammatory response at the transplant site. This effect can lead to better outcomes and increased satisfaction for patients undergoing hair transplant procedures.
Minimised Post-Transplant Hair Loss
After a hair transplant, a phenomenon called “shock loss” can occur, where the transplanted hairs fall out before regrowing. Baricitinib’s anti-inflammatory properties may help minimize this post-transplant hair loss, allowing the transplanted follicles to establish and regrow more effectively.
Side effect of Baricitinib
Note, however, that the drug can have side effects. For example, the most common are infections of the upper respiratory tract. But also headaches, acne, and high cholesterol. Sometimes we can notice an increase in the presence of the enzyme called creatine kinase.
You should know that this drug is produced by the American pharmaceutical company Eli Lilly. In addition, it is marketed under the name: Olumiant. Also, Baricitinib had already been authorized and used to treat rheumatoid arthritis. Recently its authorization was extended to patients with a severe form of Covid-19.
Following this FDA clearance, Nicole Friedland, President and CEO of the National Alopecia Areata Foundation (NAAF) said:
“This approval marks an important milestone with the first-ever FDA-approved systemic treatment for patients with alopecia. They face significant challenges every day, including limited knowledge of the disease. A lack of treatment options and social stigma”.
Baricitinib in France and in Europe
In Europe, Baricitinib has been authorised since 2020. It is used to treat moderate to severe atopic dermatitis in adults when cream treatments are ineffective.
And to conclude, in France, it has been reserved since 2021 for patients who have not improved with Ciclosporin. Or who cannot take Ciclosporin because of a contraindication or poor tolerance. Note that this same treatment is also authorized for patients with rheumatoid arthritis.
Future Directions and Considerations
While the potential benefits of Baricitinib for hair loss and hair transplant treatments are encouraging, further research is still needed to fully understand its efficacy and safety profile in these specific applications. Clinical trials involving human subjects are ongoing, and results will shed more light on the drug’s potential.
It is important to note that the FDA currently approves Baricitinib for treating rheumatoid arthritis and not specifically for hair loss or hair transplant procedures. Therefore, individuals interested in exploring Baricitinib as a treatment option for hair-related concerns should consult a qualified healthcare professional who can assess their situation and provide personalized advice.
Baricitinib, a JAK inhibitor primarily used for rheumatoid arthritis, shows significant potential as a treatment option for hair loss and hair transplant procedures. Its anti-inflammatory effects and ability to stimulate hair regrowth offer hope to those seeking effective solutions for their hair-related concerns. As research continues to unfold, Baricitinib may pave the way for innovative and non-invasive hair restoration treatments, improving individuals’ lives and confidence worldwide.
When it comes to hair loss treatments and hair transplant procedures, finding a reputable clinic with experienced professionals is crucial. Look no further than HairBack Clinic. We are a leading hair transplant clinic in Turkey with a stellar reputation for providing exceptional results and restoring hair confidence. With a team of skilled surgeons, cutting-edge technology, and a patient-centric approach, we offer comprehensive hair loss treatments tailored to each individual’s unique needs. Schedule your free consultation today!
Dr. Baykal Oymak is a highly esteemed transplant specialist hailing from Turkey, boasting an impressive 17-year tenure in the medical field. His professional journey commenced as a dermatologist at Bogazici Hospital in Istanbul, where he began to hone his expertise. Since then, Dr. Oymak has conducted a remarkable tally of approximately 14,000 triumphant hair transplant procedures within Turkey. Additionally, he holds specialization in PRP treatment and Mesotherapy, further solidifying his reputation as a versatile and accomplished practitioner in the realm of dermatology and transplantation. » SCHEDULE YOUR HAIR TRANSPLANT IN TURKEY HERE «